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Updated: Sep 12, 2025

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

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交叉链接MR1-连接物识别了维生素B6的代谢物作为TCR反应性抗原

Thierry Schmidlin1, Enas Behiry2, Hannah Thomas2

  • 1Institute of Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes-Gutenberg University, Mainz, Germany; Nuffield Department of Medicine, Centre for Immuno-Oncology, Oxford OX3 7DQ, UK.

Cell reports methods
|August 5, 2025
PubMed
概括

研究人员开发了一种新方法来识别主要组织相容性复合物I类相关蛋白1 (MR1) 配体. 这种方法确定了维生素B6的维生素,pyridoxal和pyridoxal 5'-phosphate (PLP),作为免疫性MR1配体被T细胞识别.

关键词:
CP: 免疫学 免疫学马伊特 (MAIT) 是一个名字.在MR1中,MRI是MRI.一个T细胞细胞.在TCR中,可以使用TCR.抗原呈现的呈现方式.交叉链接是指交叉链接.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量代谢物抗原是代谢物的抗原.皮里多克萨尔 (Pyridoxal) 是一种氧化物.维生素B6 维生素B6 是一种维生素.

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