氨酸分子重量在HIF-1α通路介导的低氧微环境重编程中的关键作用
Jing Liu1, Meishan Piao2, Yunxing Li1
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
International journal of biological macromolecules
|August 5, 2025
概括
具有特定分子量的氨酸 (HA) 有效地对抗组织缺氧,促进伤口愈合. 这项研究揭示了HAHA.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 组织工程是组织工程.
背景情况:
- 慢性伤口愈合因组织缺氧而显著延迟.
- 目前的氧气输送材料在长期生物安全性和稳定性方面面临着挑战.
- 氨酸 (HA) 在减轻缺氧损伤方面的潜力尚未被探索.
研究的目的:
- 为了研究不同分子重量的氨酸 (HA) 的抗低氧作用.
- 阐明HA在减轻缺氧损伤中的结构-活性关系.
- 探索HA在低氧性疾病中的治疗潜力.
主要方法:
- 酶性水解用于制备具有不同分子量 (HA I,HA II,HA III) 的HA样本.
- 结构特征确定了HA样本的链形状.
- 在体外测试中评估了HA在缺氧下减轻氧化和炎症损伤的能力.
- 在体内实验中评估了HA在促进 hypoxic 组织中的血管生成和表皮再生方面的有效性.
主要成果:
- 在低氧条件下,HA显示出对氧化和炎症损伤的保护作用.
- HA II (Mw ≈ 30.8 kDa) 显示出最强大的抗低氧活性.
- 抗低氧机制涉及HIF-1α的调节.
- 在体内研究证实,HA II在缺氧组织中促进血管生成和表皮再生.
结论:
- 在HA的分子量,链形状和其抗低氧功效之间存在明确的结构-活性关系.
- 酶性水解是一种可行的策略,可以增强HA的治疗潜力.
- HA,特别是HA II,显示出作为慢性伤口和其他缺氧状况的治疗剂的希望.
相关概念视频
Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
Hypoxia
1.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.2K
Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Histone Modification
14.0K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.0K
Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K


