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Updated: Sep 12, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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调节由RING E3泛素连接酶通过关键基残留物进行泛素转移

Mark A Nakasone1, Lori Buetow2, Mads Gabrielsen2

  • 1Cancer Research UK Scotland Institute, Glasgow, UK mark.nakasone@glasgow.ac.uk.

Life science alliance
|August 5, 2025
PubMed
概括

在RING泛素连接酶中的关键 (LP) 残留物对于泛化至关重要. 这种残留物的变化会影响E2∼Ub结合和催化 conformation,影响基质的ubiquitination.

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