红枣皮外体样纳米颗粒 (TPELNs) 通过肠道微生物组重塑和免疫调节减轻肠道炎症
Ran Tuo1, Yingjie Huang1, Xiangfeng Chen1,2
1College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Journal of agricultural and food chemistry
|August 5, 2025
概括
果皮外体样纳米颗粒 (TPELNs) 通过调节免疫反应和肠道微生物群,有效地减少了小鼠的肠道炎症. 这些植物衍生的纳米颗粒显示出作为功能性食品成分对消化健康的承诺.
科学领域:
- 植物生物学 植物生物学
- 纳米技术 纳米技术
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
背景情况:
- 植物外体样纳米粒子 (PELNs) 正在成为潜在的治疗剂.
- 皮外体样纳米颗粒 (TPELNs) 尚未广泛研究其抗炎性质.
研究的目的:
- 在严重肠道炎症的小鼠模型中研究TPELNs的治疗潜力.
- 评估TPELNs对结肠组织损伤,免疫反应,肠道微生物群和代谢物的影响.
主要方法:
- 通过差分离心和PEG沉,从普通皮中分离出TPELN.
- 使用德克斯硫酸盐 (DSS) 诱导的小鼠模型来模拟肠道炎症.
- 分析包括结肠组织损伤评估,炎症标志物表达 (iNOS,Tnf-α,Il-1β,Il-10),肠道微生物群分析和代谢物分析.
主要成果:
- TPELNs显著缓解了DSS诱导的肠炎症状,并减少了结肠组织损伤.
- TPELNs抑制了促炎性标记物 (iNOS,Tnf-α,Il-1β) 并促进了抗炎性细胞因子Il-10.
- TPELNs通过增加有益的Firmicutes和改变特定的代谢物,如醇碳酸硫酸盐和硫醇酸等来调节肠道微生物群.
结论:
- TPELN在肠道中显示出显著的抗炎作用.
- TPELNs代表了对肠道炎症的一种有前途的天然治疗剂.
- 可以将TPELN开发为功能性食品成分,以支持消化健康.
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