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Updated: Sep 12, 2025

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查加斯疫苗候选物TCPOPOP的开放和闭合形状的冷EM带头分析

Sagar Batra1,2, Francisco Olmo3, Timothy J Ragan4

  • 1School of Biosciences, Division of Microbiology, Brewing and Biotechnology, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.

Nature communications
|August 5, 2025
PubMed
概括

研究人员确定了Trypanosoma cruzi蛋白 (TcPOP) 的3D结构,这是一个有前途的查加斯病疫苗候选人. 免疫研究表明,TCPOP引起的反应可以溶解寄生虫并阻止入侵.

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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