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Updated: Sep 12, 2025

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

Published on: March 18, 2017

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DDX41解决了G-四重复合,以保持红色素基因组完整性,并防止cGAS介导的细胞死亡

Honghao Bi1,2, Kehan Ren1,2, Pan Wang1,2

  • 1Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Nature communications
|August 5, 2025
PubMed
概括

有害的DDX41变体与髓状瘤有关. 这项研究揭示了DDX41可以解决G-四重复合体,保持红色素体基因组的稳定性,并抑制cGAS-STING通路.

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