童年不良经历与早期发病的牛皮之间的性别差异
Sarnai Arlud1,2, Hang Xu1, Yu Feng Bai2
1Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Scientific reports
|August 5, 2025
概括
童年不良经历 (ACE) 与早期发病的牛皮有关,特别是在女性身上. 较高的ACE暴露显示了剂量-反应关系,这表明早期心理干预可能有利于处于风险的个体.
科学领域:
- 皮肤病学 皮肤病学
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 牛皮是一种由遗传和环境影响的慢性自身免疫性皮肤疾病.
- 不良的童年经历 (ACE) 被认为是重要的环境压力因素.
- 与晚发型相比,早期发病的牛皮 (≤18岁) 可能具有独特的促成因素.
研究的目的:
- 调查ACE,家族病史和早期发病的牛皮之间的关联.
- 探索ACE和早期发病的牛皮之间的关系中的性别差异.
- 为了确定与早期发病的牛皮相关的特定ACE.
主要方法:
- 横截面研究设计. 截面研究设计.
- 包括102名牛皮患者 (54名早期发病,48名晚期发病).
- 多变量回归和性别分层分析来评估关联.
主要成果:
- 早期发病的牛皮患者的女性,父母牛皮和焦虑率更高.
- 暴露于三种或更多的ACE与早期发病的牛皮明显相关 (aOR=2.61,p=0.014).
- 特定的ACE如情绪疏忽,家庭暴力和孤独与早期发病的牛皮有关. 这种联系在女性中比男性更为强烈.
结论:
- ACEs,特别是更高的暴露水平,与早期发病的牛皮有显著的关联.
- 在ACE和早期发病的牛皮之间存在剂量反应关系.
- 早期的心理干预对有风险的人来说可能是有益的,特别是女性有显著的ACE暴露.
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