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通过通过光和声音穿过头骨来成像大脑

Héctor Estrada^1,2, Thomas Deffieux³, Justine Robin³

¹Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich, Switzerland.

Nature biomedical engineering

|August 5, 2025

概括

先进的成像技术,如超高分辨率超声波和光声学提供非侵入性大脑探索. 克服骨扭曲是释放它们在神经科学和医学中的全部潜力的关键.

科学领域:

神经成像是一种神经成像.
生物医学光学生物医学光学
声学声学在声学方面

背景情况:

传统的光学和超声波脑成像方法受到低分辨率或侵入性的限制.
头骨骨头骨对跨体成像应用构成重大障碍.
目前关于头骨声学特性的知识不足以用于先进的成像方式.

研究的目的:

为了回顾通过头骨的跨波传播的挑战.
讨论描述和补偿头骨引起的扭曲的策略.
总结当前的应用和未来的挑战在非侵入性脑成像.

主要方法:

检查横波传播物理学的研究.
头骨骨声学特性的表征和建模.
对图像扭曲的补偿策略的审查.

主要成果:

超高分辨率超声波,光学和光声学技术使多层次的大脑审讯成为可能.
头骨骨显著扭曲光和声波,限制了跨的应用.
正在开发新的方法来建模和纠正这些扭曲.

结论:

影像技术的进步需要对骨声学有更深入的了解.
对头骨引起的扭曲进行补偿对于非侵入性和最小侵入性脑成像至关重要.
这一跨学科领域对未来的医学诊断和研究充满希望.

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