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Updated: Sep 12, 2025

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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GAGA指转录因子通过1D-3D促进扩散搜索染色素

Xinyu A Feng1,2,3, Maryam Yamadi1, Yiben Fu2,4

  • 1Department of Biology, Johns Hopkins University, Baltimore, MD, USA.

Nature structural & molecular biology
|August 5, 2025
PubMed
概括

细胞转录因子 (TFs) 使用1D-3D扩散导航DNA和染色质以找到目标位点. 核细胞阻碍但不能阻止这种促进的扩散,使基因调节.

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Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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