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Updated: Sep 12, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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矩阵-M辅助剂触发炎酶激活,并通过诱导溶酶体膜通透的诱导使抗原交叉呈现

Behdad Zarnegar1, Berit Carow2, Jens Eriksson3

  • 1Novavax AB, Uppsala, Sweden.

NPJ vaccines
|August 5, 2025
PubMed
概括

由Matrix-A和Matrix-C组成的Matrix-M辅助剂通过诱导树突细胞中的溶酶体膜通透 (LMP) 来增强免疫反应. 这种机制解释了如何使用Matrix-M辅助剂的疫苗有效地促进CD8+T细胞的反应.

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