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14-3-3结合使帕金森相关激酶LRRK2保持在一个不活跃的状态

Juliana A Martinez Fiesco1, Alexandra Beilina2, Astrid Alvarez de la Cruz1

  • 1Kinase Complexes Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

Nature communications
|August 5, 2025
PubMed
概括

14-3-3蛋白与丰富的白素重复激酶2 (LRRK2) 结合,抑制其活性,这对帕金森病 (PD) 发病至关重要. 这项研究揭示了这种相互作用的结构基础,为PD提供了新的治疗点.

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