在内分泌过程中NOTCH3的细胞外域脱落与不同CADASIL突变激活机制之间的异质性有关

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Updated: Sep 12, 2025

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

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Samira Hosseini-Alghaderi1, Martin Baron2

  • 1School of Biological Sciences, University of Manchester, Michael Smith Building, Oxford Rd, Manchester, M13 9PY, UK. samira.hosseini@manchester.ac.uk.

Cell communication and signaling : CCS
|August 5, 2025
PubMed
概括

在CADASIL中,NOTCH3的基底内细胞因子会导致细胞外域 (ECD) 脱落,这是一种与中风和痴呆症相关的疾病. 了解这些机制可能会导致针对小血管疾病的新疗法.

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