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Updated: Sep 12, 2025

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人类TOPIIa由凝聚素脱链的基质可访问性调节

Erin E Cutts1,2, Sanjana Saravanan1, Paul Girvan3,4

  • 1DNA Motors Group, MRC Laboratory of Medical Sciences, Du Cane Road, London, W12 0HS, UK.

Nature communications
|August 5, 2025
PubMed
概括

人类拓酶IIαα (TOP2α) 解锁DNA,但受到高强度和特定DNA几何结构的阻碍. 与DNA结合的凝聚素阻断了TOP2α活性,揭示了一个新的调节机制.

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