基于风险的查对上部胃肠道癌症的影响:一个多中心的现实研究
Hongrui Tian1, Mengfei Liu1, Zhen Liu1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital & Institute, Beijing, China.
British journal of cancer
|August 5, 2025
概括
对上部胃肠道 (UGI) 癌症进行基于风险的查是可行的,并且具有成本效益. 与普遍查相比,这种策略显著提高了癌症检测率,降低了成本,显示出更广泛应用的希望.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 上部胃肠道 (UGI) 癌症查旨在通过早期检测改善结果.
- 传统的普遍查方法可能资源密集且效率较低.
- 制定有针对性的查策略对于优化癌症检测和资源配置至关重要.
研究的目的:
- 评估基于风险的UGI癌症顺序查方法的可行性,有效性和成本效益.
- 评估基于问卷的定量模型,用于识别UGI癌症查的高风险个体.
- 将基于风险的查结果与历史的普遍查数据进行比较.
主要方法:
- 在中国的两个地区 (龙德和立通) 实施了基于风险的查策略.
- 参与者完成了基于问卷的风险评估,以确定高风险个人.
- 高风险的参与者随后被邀请进行内镜查.
主要成果:
- 在9492名参与者中,26.89%被确定为高风险,其中46.94%接受了内镜检查.
- 基于风险的查显示检测率是普遍查的2.28倍 (p=0.002).
- 与普遍查相比,每个检测到的病例和每个早期检测到的病例的平均成本明显较低 (分别减少30.76%和28.99%).
结论:
- 基于风险的顺序查是检测UGI癌症的可行和有效方法.
- 这种方法被证明是具有成本效益的,在检测整体和早期UGI癌症方面节省了大量资金.
- 该研究支持在其他地区更广泛地实施基于风险的查策略的潜力.
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