一种基于拉曼光谱和深度学习的智能辅助精神分裂症查的新方法
Meng Xiao1, Sulidan Xiaokaiti2, Meng Shang1
1Quzhou KeCheng People's Hospital, Quzhou, China.
Scientific reports
|August 6, 2025
概括
这项研究引入了血清拉曼光谱用于精神分裂症查,与1D光谱分析相比,使用来自马尔科夫过渡场 (MTF) 的2D光谱获得更好的结果.
科学领域:
- 生物医学光谱学 生物医学光谱学
- 神经科学是一个神经科学.
- 医疗保健中的机器学习
背景情况:
- 精神分裂症的诊断仍然具有挑战性,需要新的生物标志物.
- 血清拉曼光谱为疾病检测提供了一种非侵入性的方法.
- 当前的光谱分析方法可能无法完全捕捉复杂的光谱模式.
研究的目的:
- 开发一种使用血清拉曼光谱的精神分裂症辅助查方法.
- 探索马尔科夫过渡场 (MTF) 在分析拉曼光谱数据中的实用性.
- 为了比较1D和2D谱分析对精神分裂症的诊断性能.
主要方法:
- 从精神分裂症患者和健康对照组中收集了血清拉曼光谱.
- 用四个卷积神经网络来分类光谱数据.
- 引入了马尔科夫过渡场 (MTF) 来将1D拉曼光谱转换为2D光谱图.
- 开发并比较基于1D光谱序列和2DMTF光谱图的机器学习模型.
主要成果:
- 开发的方法证明了对精神分裂症的辅助查能力.
- 使用MTF丰富光谱分析将1D拉曼光谱转换为2D光谱图.
- 在2D MTF光谱图上训练的模型与在1D光谱序列上训练的模型相比,表现出更高的性能.
结论:
- 血清拉曼光谱学,增强了基于MTF的2D光谱分析,显示出作为精神分裂症查工具的希望.
- 整合MTF为拉曼光谱数据处理提供了一种新的方法.
- 这种方法在早期发现和治疗精神分裂症方面提供了潜在的进步.
相关概念视频
01:20Raman Spectroscopy: Overview
601
The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
601
01:26Raman Spectroscopy Instrumentation: Overview
532
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
532