昼夜综合征及其组成部分与Helicobacter pylori感染风险之间的关系:一个横截面研究
Haiyan Yang1, Liuying He1, Xiao Zhao1
1Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
BMC infectious diseases
|August 6, 2025
概括
循环节综合征 (CircS) 是Helicobacter pylori (H. pylori) 感染的一个独立风险因素. 吸烟改变了这种关系,中心肥胖和高血压等因素与增加的H. pylori风险有关.
科学领域:
- 代谢健康研究研究
- 传染病流行病学 传染病流行病学
- 肠道微生物组研究的研究
背景情况:
- 循环节综合征 (CircS) 提供了比代谢综合征 (MetS) 更全面的代谢健康观点.
- 关于CircS和Helicobacter pylori (H. pylori) 感染之间的关联存在有限的研究.
- 这项研究调查了CircS及其组成部分和H. pylori感染在接受健康查的个体之间的联系.
研究的目的:
- 为了确定CircS是否与H.pylori感染有关.
- 为了确定与H. pylori感染相关的特定CircS组件.
- 为了探索吸烟对CircS-H. pylori关系的修饰作用.
主要方法:
- 对29621名在中国西北地区接受健康检查的人进行横截面研究 (2021年7月至2023年6月).
- 用13C尿素呼吸试验 (13C-UBT) 确定H. pylori感染状态.
- 用于评估H. pylori感染与CircS及其组件之间的关联的二元逻辑回归分析,对共变量进行调整.
主要成果:
- 甲状腺菌感染与CircS的更高患病率 (OR 1.17,P < 0.001) 有显著的关联,吸烟作为修饰因素.
- 中心肥胖,低高密度胆固醇,高血压和睡眠不足与增加的H. pylori感染风险显著相关.
- 在H. pylori感染和抑郁症,高FBG或高TG之间没有发现显著的关联.
结论:
- 循环节综合征 (CircS) 被确定为H. pylori感染的独立风险因素.
- 吸烟状态显著改变了CircS和H.pylori感染之间的关联.
- 特定的CircS组件,包括中心肥胖和高血压,与H. pylori感染有关.
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