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Updated: Sep 12, 2025

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基于细胞的测试对预测对TNF抑制剂治疗的反应的效力

Noa Rose1,2, Ari Polachek2,3, Daniel Levinson1,3

  • 1Department of Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Expert review of molecular diagnostics
|August 6, 2025
PubMed
概括

预测患者对瘤亡因子抑制剂 (TNFi) 的反应至关重要. 使用生物标志物的基于细胞的测定 (CBA) 可以指导为个体患者选择最有效的TNFi,改善治疗结果.

关键词:
类风湿性疾病 类风湿性疾病TNF 抑制剂可以抑制TNF.生物标志物 生物标志物基于细胞的测定.药物反应预测 药物反应预测免疫反应的免疫反应.周围血液中的单核细胞.

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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