老年人的脆弱及其组成部分和心血管结果:全国性的流行病学研究
Kensuke Ueno1,2, Toshiyuki Ko1,3, Yuta Suzuki1,4
1Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Geriatrics & gerontology international
|August 6, 2025
概括
老年人的脆弱性显著增加了心血管疾病 (CVD) 的风险. 全面的脆弱性评估对于识别高风险个体和实施预防策略至关重要.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 虚弱是一种多因素状况,影响老年人的身体,认知和社会福祉.
- 多因素定义的脆弱性和心血管疾病 (CVD) 风险之间的关系仍未得到充分研究.
研究的目的:
- 调查多因素定义脆弱性及其组成部分与老年人心血管疾病发病率之间的关联.
- 澄清综合脆弱性评估在心血管疾病风险分层中的作用.
主要方法:
- 使用了全国性的索赔数据库,包括66,948名65岁及以上的参与者,以前没有CVD.
- 脆弱性被评估使用一个调查问卷,涵盖身体,认知,口腔,营养和社会方面.
- 主要结局是心血管疾病事件的复合,包括缺血性心脏病,心力衰竭和中风.
主要成果:
- 与强壮个体相比,脆弱与患心血管疾病的风险增加41% (aHR1.41,95% CI 1.31-1.52) 相联系.
- 所有评估的脆弱成分 - - 身体功能,营养,口腔健康,认知和社会方面 - - 独立预测心血管疾病风险增加.
- 这些关联在整个心血管疾病亚型中是一致的.
结论:
- 多因素脆弱性评估有效地对日本老年人心血管疾病风险进行了分层.
- 脆弱的每个组成部分独立地对心血管疾病的可能性有所贡献,突出了全面评估的必要性.
- 综合脆弱性评估对于老龄人口的预防性护理至关重要.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.7K
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
10.4K
相关概念视频
The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K
Heart Failure III: Clinical Manifestations
47
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
47
Assessment of the Cardiovascular System I: Subjective Data
467
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
467
Heart Failure II: Pathophysiology
41
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
41
Aging
183
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
183
Coronary Artery Disease III: Clinical Manifestations
34
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
34
