碳水化合物加载饮食和肠道微生物组之间的相关性:系统性审查
Omar El-Kholy1, Lindsey Nichols2, Ahmed Adham R Elsayed2,3,4
1Faculty of Medicine, Alexandria University, Alexandria, Alexandria, Egypt.
MicrobiologyOpen
|August 6, 2025
概括
富含碳水化合物的饮食显著改变肠道微生物群,影响健康. 高脂肪饮食增加了Firmicutes与Bacteroidetes的比率,这是与肥胖有关的标志物.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 代谢研究研究 代谢研究
背景情况:
- 肠道微生物组在宿主消化,新陈代谢和整体健康方面发挥着至关重要的作用.
- 代谢综合征是一个重要的人类健康问题,可以在动物模型中使用碳水化合物加载饮食来研究.
- 了解饮食与微生物群的相互作用是解决代谢障碍的关键.
研究的目的:
- 系统地审查碳水化合物加载饮食对动物肠道微生物群的影响.
- 分析不同类型的碳水化合物如何影响肠道微生物群组成和相关的生理结果.
- 识别将特定饮食模式与代谢健康标志物联系在一起的模式.
主要方法:
- 在五个主要数据库中进行了系统的文献搜索,截至2024年9月.
- 这项审查包括了17项涉及690多只动物的动物研究.
- 使用SYRCLE的工具对包括的研究进行了偏差风险评估.
主要成果:
- 富含碳水化合物的饮食显著改变了肠道微生物组合,多样性和Firmicutes与Bacteroidetes (F/B) 的比率.
- 高碳水化合物,高脂肪饮食始终增加了F/B比率,这是与人类肥胖相关的转变.
- 不同类型的碳水化合物 (如果糖,糖) 对微生物组和宿主生理学产生了多种影响,包括血压和肠道完整性.
结论:
- 富含碳水化合物的饮食对肠道微生物群和宿主生理有不同的影响.
- 高脂肪碳水化合物饮食,与基于粉的饮食不同,往往会提高F/B比率.
- 进一步的研究是必不可少的,以充分阐明饮食,肠道微生物群和动物和人类的代谢健康之间的复杂相互作用.
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