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相关概念视频

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

5.1K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
5.1K
Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

6.7K
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
6.7K
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

8.1K
Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
8.1K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.4K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.4K
Acid Halides to Ketones: Gilman Reagent01:14

Acid Halides to Ketones: Gilman Reagent

3.1K
Lithium dialkyl cuprate, also known as Gilman reagents, selectively reduces acid halides to ketones. The acid chloride is treated with Gilman reagent at −78 °C in the presence of ether solution to produce a ketone in good yield.
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen...
3.1K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

10.8K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
10.8K

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相关实验视频

Updated: Sep 12, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

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铜单原子催化剂用于Thioether合成中的高效C─S合.

Theodore A Gazis1, Shilpa Palit1, Luis A Cipriano1

  • 1Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, Milano, 20133, Italy.

Angewandte Chemie (International ed. in English)
|August 6, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种可回收的铜单原子催化剂,用于高效的碳硫键形成. 这一突破解决了合成用于制药和材料的乙烯的挑战,为传统方法提供了更绿色的替代方案.

关键词:
交叉合反应 交叉合反应C─S 债券形成密度函数理论密度函数理论精细化学合成 精细化学合成一个原子的催化剂.

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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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相关实验视频

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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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科学领域:

  • 不同质的催化剂.
  • 材料科学是一种材料科学.
  • 有机合成 有机合成

背景情况:

  • 碳-硫 (C─S) 键的形成对于合成用于制药,农业化学品和材料中的硫乙烯非常重要.
  • 目前用于C-S合的工业方法通常使用昂贵的同质催化剂,可回收性差,易受硫中毒的影响.
  • 开发高效,选择性和强大的C-S交叉合催化剂仍然是合成化学的一个重大挑战.

研究的目的:

  • 为碳-硫 (C─S) 交叉合反应开发一种高效,选择性和可回收的催化剂.
  • 为了研究一个铜单原子催化剂的使用,在中相孔石墨碳化物上支持C-S键形成.
  • 提供对催化过程的机械洞察力,并证明其在温和条件下在克拉尺度上适用性.

主要方法:

  • 一个铜单原子催化剂的合成和表征原子分散在半孔石墨碳化物上.
  • 在温和条件下测试催化剂在碳-硫 (C-S) 交叉合反应中的性能.
  • 使用先进的特征技术 (电子显微镜,X射线吸收光谱,EELS) 和计算模拟 (DFT) 进行机械研究.

主要成果:

  • 铜单原子催化剂在C-S交叉合反应中表现出高效率和选择性.
  • 催化剂表现出极好的抗醇中毒性,并在多个催化循环中保持高性能,证实了其可回收性.
  • 机理学研究支持了协调的氧化添加途径,排除了中间激素,并证实了Cu位点的原子分散和稳定性.

结论:

  • 在半孔石墨碳化物上原子分散的铜作为C-S交叉合的高效异质催化剂.
  • 这种单原子催化剂方法克服了传统方法的局限性,提供了增强的稳定性,可回收性和对硫中毒的抗性.
  • 这些发现为使用C-S键形成的精细化学品和制药品的更绿色,更可扩展的合成过程铺平了道路.