术前的tamsulosin是否有助于半硬性尿路镜治疗下尿路结石? 一个前性,随机的双盲研究
Ahmed A Shahat1, Ahmad A Elderwy1, Mahmoud A Gaber1
1Urology Department, Faculty of Medicine, Assuit University Hospital, Assiut, Egypt.
Current urology
|August 6, 2025
概括
术前的坦苏洛辛显著减少了手术时间,并且在尿管下方结石的尿管扩张和支架 (URS) 期间需要尿管扩张和支架,从而提高了手术成功率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌病学 在内分泌病学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 尿道透视 (URS) 是尿道结石的标准治疗方法,具有很好的结果.
- 阿尔法阻塞剂,如坦苏洛辛,已经被研究了它们通过促进尿道扩张来促进URS的潜力.
- 之前的研究表明,阿尔法阻断剂可能会改善无结石率,并减少并发症,而不是安慰剂或没有药物.
研究的目的:
- 评估手术前坦苏洛辛给药对URS手术内和术后结果的影响.
- 具体评估其对治疗下尿道结石的影响.
主要方法:
- 一个双盲,随机,安慰剂控制的临床试验,涉及80名患者.
- 患者被分配到坦苏洛辛组或安慰剂组 (每组40名患者).
- 随机化是在2019年12月至2021年11月期间在阿苏特泌尿外科和科医院使用闭包方法进行的.
主要成果:
- 在患者年龄,石块大小或阻塞程度方面,两组之间没有发现显著差异.
- 与安慰剂组相比,tamsulosin组的手术时间显著缩短 (61.50 ± 23.99 分钟),而安慰剂组 (79.80 ± 23.22 分钟; p = 0.001).
- 需要尿管扩张 (20%与80%相比; p < 0.001) 和术后尿管支架 (22.5%与60%相比; p = 0.001) 在坦苏洛辛组显着较低.
结论:
- 术前的坦苏洛辛给药对URS在管理下尿道结石方面有好处.
- 它导致手术时间缩短,尿管扩张的需求减少,以及对术后支架的需求减少.
- 坦素增加了URS的成功率,但没有显著影响并发症率.
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