补充-ARIE:催化新方法方法论的开发和采用
Kristifor Sunderic1, Andrew M Wright2, Nicole Kleinstreuer2,3
1National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
概括
新方法方法 (NAM) 为研究提供了先进的工具,补充了动物模型. 美国国家卫生研究院 (NIH)
科学领域:
- 毒理学和药理学研究.
- 生物医学科学和药物开发.
- 监管科学和标准化.
背景情况:
- 新方法方法 (NAM) 在研究中越来越重要,为动物试验提供了替代方案和补充.
- 美国国家卫生研究院 (NIH) 已大幅增加对各种NAM的投资,包括化学,和体外系统.
- 现有的NAM需要进一步开发,标准化和验证,以便更广泛地应用.
研究的目的:
- 引入NIH共同基金的动物实验研究补充 (补充-ARIE) 计划.
- 概述该计划的目标:推进组合NAM,以准确地进行人类生物学建模,以特定人群为特征的结果,并获得监管机构的接受.
- 详细介绍战略规划活动,为Complement-ARIE的实施提供信息.
主要方法:
- 美国国立卫生研究院组织了战略规划,包括一个机构间的撤退,公众听证会和文献分析.
- 一个挑战奖项被用来刺激NAM发展的创新.
- 对科学文献进行分析,以了解NAMs的当前形势.
主要成果:
- 战略规划确定了NAM实施的关键科学和运营机遇和挑战.
- 结果将指导NAM的开发,标准化,验证和监管使用.
- 该计划旨在通过补充传统动物模型来提高研究的效率和有效性.
结论:
- 补充-ARIE计划已准备好催化NAM的创新.
- 成功实施将导致NAM在基础,翻译和临床科学中的更广泛接受和影响.
- 这些进展预计将改变科学研究方法.
关键词:
在实验中补充动物研究,补充-ARIE.国家卫生研究院,NIH.新方法方法论,新型替代方法,NAMs.在化学品行业,在的中.在体外 (in vitro) 的情况下.微生理系统,MPS,微生理系统.更多相关视频
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