口腔状细胞癌的药理治疗;一个漫长的非编码RNAs (长ncRNAs) 故事
Azita Sadeghzade1, Ali Jafarian2, Amir Hossein Davodpour2
1Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
International journal of molecular and cellular medicine
|August 6, 2025
概括
长非编码RNAs (lncRNAs) 在口腔状细胞癌 (OSCC) 的进展和耐药性方面至关重要. 针对lncRNAs提供了新的治疗策略,以提高口腔癌治疗疗效和患者存活率.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的癌症,由于晚期诊断,其生存率很低.
- 目前的药物治疗面临挑战,特别是耐药性,影响患者的治疗结果.
- 长非编码RNAs (lncRNAs) 越来越多地被认为对癌症的发展和治疗反应的作用.
研究的目的:
- 分析口腔癌的药物治疗方法.
- 阐明长非编码RNAs (lncRNAs) 在OSCC进展和耐药性的作用.
- 确定改善OSCC治疗疗效的潜在治疗点.
主要方法:
- 对口腔癌的药物治疗方法的综合文献综述.
- 分析长非编码RNAs (lncRNAs) 在基因调节,瘤生长和OSCC药物耐药性机制中的作用.
- 探索瘤微环境和免疫反应在口腔癌进展中的相互作用.
主要成果:
- 长非编码RNAs (lncRNAs) 显著影响OSCC发育和耐药性,其中一些促进或抑制瘤生长并影响化疗疗效率.
- 耐药性仍然是OSCC治疗的主要障碍,需要新的治疗策略.
- 瘤微环境中的炎症可能会加速口腔癌的进展.
结论:
- 长非编码RNAs (lncRNAs) 代表了提高OSCC治疗策略的关键分子标.
- 了解lncRNAs,瘤微环境和免疫反应之间的相互作用对于改善患者的治疗结果至关重要.
- 整合分子洞察力,特别关注lncRNAs,可以帮助克服药物耐药性,提高口腔癌治疗中的生存率.
相关概念视频
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
siRNA - Small Interfering RNAs
17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K


