在肺高血压 (EDIPHY) 中脱水氨的作用:一个随机,双盲,安慰剂控制的交叉试验
Rachel Sanders1, Thomas Walsh2, Grayson L Baird1,3
1Brown University Health, Providence, RI.
medRxiv : the preprint server for health sciences
|August 6, 2025
概括
脱氨 (DHEA) 在肺动脉高血压 (PAH) 患者中没有改善右心室 (RV) 纵向应变. 然而,DHEA在其他PAH指标中显示出潜在的益处,并被发现是安全和耐受良好.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 肺部医学 肺部医学
背景情况:
- 肺动脉高血压 (PAH) 与脱水氨 (DHEA) 和其硫酸盐形式 (DHEA-S) 的缺乏有关.
- 较低的DHEA-S水平与右心室 (RV) 功能恶化和PAH患者的生存率降低相关.
研究的目的:
- 研究DHEA补充剂在改善PAH患者的RV功能方面的疗效.
- 用心磁共振成像 (MRI) 和其他临床终点来评估RV功能变化.
主要方法:
- 在26名PAH参与者中进行了一项随机,双盲,安慰剂控制的交叉试验.
- 主要结局是DHEA治疗18周后通过MRI测量RV纵向应变的变化.
- 二级结局包括血清DHEA-S水平,emphasis-10得分和简短的形式-36物理组件得分.
主要成果:
- DHEA并没有显著改善RV纵向应变.
- 补充DHEA改善了RV短轴辐射应变,EMPHasis-10分数和SF-36物理组件分数.
- 血清DHEA-S和丸激素水平随着DHEA治疗显著增加;较高的DHEA-S与改善的PAH指标相关.
- DHEA可能加剧了RV周围应变,并与丸激素水平的增加有关,可能会抵消效应.
结论:
- 在这项试点PAH研究中,DHEA治疗没有改善RV纵向菌株.
- DHEA在其他PAH终点上表现出可变的影响,并且安全且耐受良好.
- 增加的DHEA-S和水平可能解释了混合结果,需要进一步调查.
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