下皮层激活和功能连接的改变是ASD中被动听觉空间注意力的特征
Sergio Osorio1,2, Jasmine Tan1,2, Grace Levine1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
bioRxiv : the preprint server for biology
|August 6, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童在听觉空间注意力任务中表现出大脑活动和连接性的改变. 神经反应中的这些差异可能解释了处理声音和社交线索的挑战.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 审计处理 审计处理
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响社会互动和沟通的神经发育状况.
- 对于社交线索至关重要的听觉空间注意力在ASD中被研究不足.
- 之前的研究表明,ASD患者的听觉处理不典型.
研究的目的:
- 研究ASD儿童被动听觉空间注意力的神经特征.
- 为了比较ASD中的大脑活动和功能连接与典型发育 (TD) 儿童.
- 探索神经发现和ASD行为结果之间的关系.
主要方法:
- 在患有自闭症儿童 (n=21) 和TD对照组 (n=31) 中使用源局部化磁脑电图 (MEG).
- 参与者被动地倾听听觉刺激,其位置要么稳定 (停留),要么改变 (跳跃).
- 进行了线性混合效应建模和功能连接性分析.
主要成果:
- 与TD儿童相比,患有自闭症的儿童在"跳跃"试验期间表现出听力皮质下部皮质激活.
- 在ASD中,在听觉皮层和前额/副额区域之间观察到更高的α频段功能连接.
- 连接模式与听觉处理得分和ASD症状严重程度相关.
结论:
- 听觉空间注意力,包括被动的声音方向,在ASD患者中看起来不同.
- 听觉和注意力网络中神经活动和连接的改变可能是这些差异的基础.
- 这些发现有助于理解ASD的感官处理变异.
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