线粒体对心理压力的反应及其中间前额生物标志物相关联
bioRxiv : the preprint server for biology
|August 6, 2025
概括
一项新的压力测试显示,挑战后唾液细胞自由线粒体DNA (cf mtDNA) 的升高. 这种与大脑乳酸盐和mPFC厚度相关的反应,为研究压力和线粒体提供了一种新方法.
科学领域:
- 神经科学是一个神经科学.
- 线粒体生物学 线粒体生物学
- 压力研究 压力研究
背景情况:
- 应激反应需要增加线粒体活动以满足能源需求.
- 中间前额皮层 (mPFC) 调节压力诱导的线粒体通路.
- 现有的人类模型研究压力线粒体反应是有限的.
研究的目的:
- 建立一个临床上可访问的范式来研究人类的压力线粒体反应.
- 调查心理压力,唾液细胞无线粒体DNA (cf mtDNA) 和大脑特征之间的联系.
主要方法:
- 在35名健康个体中利用心理压力挑战.
- 在压力之前和之后测试的唾液cfmtDNA水平.
- 在mPFC中与大脑代谢物 (MRS) 和皮质厚度 (成像) 相对应的cf mtDNA反应.
主要成果:
- 唾液cf mtDNA在压力后显著增加 (p=2.0x10-7) 然后下降.
- 较高的基线dACC乳酸盐水平与cf mtDNA反应相关 (r=0.80,p<0.001).
- 增加的cf mtDNA反应与较薄的背中前额叶皮层相关 (r=-0.52,p=0.01) 并显示出U形的年龄效应.
结论:
- 压力挑战与唾液CF mtDNA检测相结合,提供了一种非侵入性方法.
- 这种范式可以在衰老和神经精神疾病中评估压力-线粒体通路功能.
- 这些发现提供了关于压力,线粒体和大脑结构之间的相互作用的见解.
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