状路径相反地沿着决策轴转移皮质活动.
Jounhong Ryan Cho1, Scott S Bolkan1, Lindsey S Brown1
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
bioRxiv : the preprint server for biology
|August 6, 2025
概括
基底腺节是基底腺节.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 系统神经科学 系统神经科学
背景情况:
- 基底和皮质形成运动,边缘和认知功能的并行循环.
- 经典模型表明,直接和间接的基底腺路径对皮质活动有相反的影响.
- 这些通路在认知功能中的对手控制在很大程度上仍未被探索.
研究的目的:
- 为了调查直接和间接的基底腺路径是否对认知功能施加对手控制.
- 为了检查操纵这些途径在决策任务期间对前带带皮层 (ACC) 活动的影响.
主要方法:
- 在小鼠的ACC和背中条体 (DMS) 中的电生理记录.
- 在积累证据任务期间,抑制DMS中直接或间接途径神经元.
- 对神经活动与决策变量和证据积累有关的分析.
主要成果:
- 基底腺路的操纵并没有改变ACC的整体活性.
- 在编码积累的感官证据的ACC神经元子群中观察到对手控制.
- 路径效应是决定变量的编码的特征,通过证据调整进行调制.
结论:
- 基底腺路径表现出功能特异性,对手控制了决策变量的皮质编码,而不是整体活动.
- 这种特异性可能扩展到其他基底结环,通过选择和转移皮质表示来支持适应性行为.
- 这些发现挑战了经典模型,并揭示了基底腺路径在认知处理中的细微角色.
更多相关视频
07:42An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
13.8K
10:35Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
Published on: June 13, 2017
31.4K
相关概念视频
Direct Motor Pathways
2.5K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.5K
Indirect Motor Pathways
1.7K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.7K
Motor and Sensory Areas of the Cortex
4.6K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.6K
Diencephalon: Thalamus and Information Relay
2.2K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
2.2K
Major Somatic Sensory Pathways
1.3K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.3K
Somatosensory, Motor, and Association Cortex
921
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
921
