年龄和性别影响日间记忆振荡,循环节律,表达
Lauren Bellfy1,2,3, Gretchen C Pifer1,3, Megan J von Abo1
1Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.
bioRxiv : the preprint server for biology
|August 6, 2025
概括
老龄化会扰乱记忆和昼夜节律,在老年小鼠中出现性别差异. 时钟基因Per1影响白天记忆性能,为与年龄相关的记忆衰退提供了潜在的治疗标.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 衰老研究研究 衰老研究
背景情况:
- 昼夜系统调节记忆和活动,但随着年龄的增长,其控制会减弱,损害记忆力.
- 以前的研究将海马中的时钟基因Per1与雄性小鼠的日间记忆控制联系起来.
- 性别和年龄对Per1在记忆和昼夜节律中的作用的影响在很大程度上是未知的.
研究的目的:
- 研究性别和年龄如何影响记忆表现,昼夜活动,睡眠和海马 Per1 表达.
- 了解性别和年龄对记忆的日常调节的影响.
主要方法:
- 对象位置记忆 (OLM) 任务来评估空间记忆.
- 循环活动监测以跟踪日常模式.
- 用RT-qPCR量化海马 Per1基因表达以响应学习.
主要成果:
- 年轻的女性在一天中表现出一致的记忆,而老年女性则表现出白天记忆振荡.
- 年长的雄性表现出高峰记忆性能转移到夜间,与显著的昼夜节律中断.
- 学习诱导的Per1表达通常与各组的峰值记忆性能保持一致,支持Per1的作用.
结论:
- Per1在记忆的日间控制中发挥作用,性别和年龄调节了这一效应.
- 在老年人中,Per1可能是改善记忆和昼夜功能的治疗点.
相关概念视频
Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
129
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
129
Biological Clocks and Seasonal Responses
38.4K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
38.4K
Understanding Sleep
505
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
505
The Pineal Gland
2.5K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
2.5K
Factors Affecting Body Temperature
6.6K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may include:
Factors may include:
6.6K


