整个大脑协调决策形成和承诺
Adrian G Bondy1, Julie A Charlton1, Thomas Zhihao Luo1,2
1Princeton Neuroscience Institute, Princeton University, Princeton NJ, USA.
bioRxiv : the preprint server for biology
|August 6, 2025
概括
整个大脑的决策信号由单个计算协调,起源于额头区域和运动皮质,然后在全球广播. 这揭示了当地的计算如何在决策过程中成为全球大脑活动.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 决策的神经相关性广泛存在,但人们对其了解甚少.
- 整个大脑的决策信号的协调仍然是一个悬而未决的问题.
- 调查决策计算是否在不同地区共享或竞争.
研究的目的:
- 为了研究在证据积累过程中大脑范围的决策信号是如何协调的.
- 确定决策计算是否在本地生成和广播或分发.
- 识别决策信号在大脑区域的起源和传播.
主要方法:
- 从成千上万个神经元的同时进行神经记录,遍及大鼠大脑的20个区域.
- 鼠执行了一项决策任务,涉及逐渐积累的听觉证据.
- 从神经活动来解码时间变化的决策状态和决策承诺时间.
主要成果:
- 决策状态在不同区域之间有强烈的时刻对时刻的共同波动,涵盖一个单一的维度.
- 共享决策信号在前皮层区域和前条纹体中最强,最早被检测到.
- 决策承诺时间也显示出强烈的,尺寸统一的共同波动,在运动皮层中最强.
结论:
- 决策计算通过单一的主导维度在大脑中集成和共享.
- 决策信号在一个小的子网络 (额叶皮层,状体) 中计算,并在全球传播.
- 决策承诺标志着来自运动皮层的协调大脑活动的关键过渡.
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