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Updated: Sep 12, 2025

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
06:44

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells

Published on: March 1, 2024

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通过分子剂调节14-3-3σ/C-RAF"自动"抑制复合物

Markella Konstantinidou1, Holly R Vickery1, Marloes A M Pennings2

  • 1Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco 94143, United States.

bioRxiv : the preprint server for biology
|August 6, 2025
PubMed
概括

研究人员开发了新的分子粘剂来稳定C-RAF/14-3-3蛋白相互作用,这是MAPK通路障碍的关键目标. 这种方法通过调节蛋白质-蛋白质相互作用,为瘤学和RAS病提供了新的治疗策略.

关键词:
14-3-3 这是一个很好的时刻.在C-RAF中.这是一个PPI PPI.它们是共价的.碎片的合并,碎片的合并.诱导的亲近性诱导的亲近性分子粘合剂是分子粘合剂.稳定器 稳定器 稳定器

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