在精神分裂症中血液和神经元细胞外膀线粒体干扰
bioRxiv : the preprint server for biology
|August 6, 2025
概括
精神分裂症谱系障碍 (SSD) 在血液和神经元EV中显示高细胞自由线粒体DNA (cf-mtDNA),与大脑乳酸和压力有关. 这可能是精神分裂症中线粒体功能障碍的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 遗传学 遗传学 是一个
背景情况:
- 线粒体功能障碍与神经精神疾病,如精神分裂症谱系障碍 (SSD) 有关.
- 在SSD中直接体内评估大脑线粒体功能具有挑战性.
- 血液中的无细胞线粒体DNA (cf-mtDNA) 和神经元细胞外囊泡 (nEV) 是拟议的生物标志物.
研究的目的:
- 调查血液中的高cf-mtDNA水平和nEVs作为SSD中线粒体功能障碍的潜在生物标志物.
- 探索通过磁共振光谱学 (MRS) 测量的cf-mtDNA水平和大脑代谢物之间的关联.
- 检查SSD中发育性压力,创伤和cf-mtDNA水平之间的关系.
主要方法:
- 在58名SSD患者和33名健康对照人群中测量了血液cf-mtDNA水平.
- 在一个子组中评估了nEV mtDNA和大脑代谢物水平 (使用MRS).
- 分析了cf-mtDNA,乳酸水平和发育性压力/创伤之间的关联.
主要成果:
- 与对照组相比,SSD患者在血液和nEV中显著增加了cf-mtDNA.
- 在SSD患者中,较高的cf-mtDNA水平与前带皮质中脑乳酸+水平的增加相关.
- 增加的发育性压力和创伤与SSD患者中较高的cf-mtDNA水平有关.
结论:
- 血液和nEV cf-mtDNA可以作为评估精神分裂症中线粒体假设的可访问生物标志物.
- 这些发现表明,异常的生物能途径与SSD中的cf-mtDNA变化有关.
- 进一步验证可以将cf-mtDNA作为SSD研究的临床工具.
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