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Updated: Sep 12, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

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通过细胞自主和非自主机制,PTEN抑制SHH髓母细胞的生长

Zhimin Lao1, Salsabiel El Nagar1,2, Yinwen Liang1

  • 1Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York 10065, NY, USA.

bioRxiv : the preprint server for biology
|August 6, 2025
PubMed
概括

在Sonic hedgehog medulloblastoma (SHH-MB) 中的PTEN损失加速了瘤的生长和分化. 这表明PTEN突变可能会对SHH-MB患者的结果产生负面影响,特别是生殖系突变.

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