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Updated: Sep 12, 2025

Lentiviral CRISPR/Cas9-Mediated Genome Editing for the Study of Hematopoietic Cells in Disease Models
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攻击性降低胆固醇在Jak2V617F中使动脉样硬化回归正常化 克隆性血液形成

Brian D Hardaway1, Trevor P Fidler2, Mojdeh Tavallaie1

  • 1Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

bioRxiv : the preprint server for biology
|August 6, 2025
PubMed
概括

克隆性血液形成 (CH) 增加了动脉样硬化心血管疾病 (ACVD) 的风险. 积极的降低LDL胆固醇可以逆转CH驱动的炎症并促进斑块稳定,这表明对ACVD风险的潜在治疗策略.

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