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Updated: Sep 12, 2025

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通过血栓形成素激活MPL的结构基础

Amirhossein Mafi1, Matthew Bratkowski1, Jiefei Geng2

  • 1Calico Life Sciences LLC, South San Francisco, CA.

Blood vessels, thrombosis & hemostasis
|August 6, 2025
PubMed
概括

血栓形成素 (TPO) 受体,MPL和JAK2信号通路对于血小板的产生至关重要. 这项研究揭示了TPO和JAK2对MPL激活的结构基础,为骨髓增殖性瘤提供了洞察力.

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