中性粒细胞-淋巴细胞比率与成年人服用万科米辛的危急疾病的相关性:一个横截面研究
Mohammad A Alfhili1, Sahar A Alazmi1, Jawaher Mohammad Alsughayyir1
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia.
International journal of general medicine
|August 6, 2025
概括
中性粒细胞-淋巴细胞比率 (NLR) 可以帮助识别接受万科米辛 (VAN) 的患者,这些患者可能需要进入重症监护室 (ICU). 升高的NLR与更高的ICU入院率有关,作为一个有价值的早期风险标志物.
科学领域:
- 临界护理医学 临界护理医学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在接受万科米辛 (VAN) 治疗的患者中,早期风险分层是必不可少的.
- 预测重症监护室 (ICU) 入院的可靠标志物很少.
- 中性粒细胞-淋巴细胞比率 (NLR) 是一个新兴的炎症标志物.
研究的目的:
- 调查NLR的相关因子和决定因素.
- 评估与VAN治疗的成年人中NLR和ICU入院之间的关联.
主要方法:
- 对295名接受VAN治疗的成年患者的人口和临床数据的回顾性分析.
- 统计分析包括曼·惠特尼U测试,奇方测试,斯皮尔曼相关性,回归分析和AUC计算.
主要成果:
- 与非ICU患者相比,ICU患者的NLR显著升高 (p <0.0001).
- 升高的NLR独立地与增加ICU入院的可能性有关 (OR 4.25-4.40,p=0.0001).
- 对于需要ICU的NLR显示出良好的诊断能力 (AUC为0.71-0.78,p<0.0001).
结论:
- NLR是一种可访问且具有成本效益的标记物.
- 在接受VAN的重症患者中,NLR显示出补充现有标志物的潜力,用于早期风险识别.
- 优化高风险患者的早期干预是NLR所促进的.
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