儿童非对比增强功能性肺部MRI:系统性审查
Carmen Streibel1,2,3, Grzegorz Bauman4,5, Oliver Bieri4,5
1Department of Paediatrics, Division of Paediatric Respiratory Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Frontiers in pediatrics
|August 6, 2025
概括
非对比增强 (NCE) 功能性MRI为儿童提供无辐射肺部成像. 讨论了MP-MRI,PREFUL-MRI,SENCEFUL-MRI和FD-MRI等技术的临床潜力.
科学领域:
- 医疗成像医学成像
- 儿科放射学 儿科放射学
- 肺部医学 肺部医学
背景情况:
- 磁共振成像 (MRI) 非常适合儿童肺部评估,因为它缺乏电离辐射,可以进行重复测量.
- 非对比增强 (NCE) 功能性MRI技术使用标准的临床MRI系统提供局部通风和 perfusion 数据.
- 目前用于儿童的NCE-MRI方法包括矩阵-笔分解 (MP) -MRI,相位解析功能性肺 (PREFUL) -MRI,自闭式非对比增强功能性肺 (SENCEFUL) -MRI和富里埃分解 (FD) -MRI.
研究的目的:
- 为儿童肺部成像进行创新的非对比增强功能性MRI技术进行全面审查.
- 讨论MP-MRI,PREFUL-MRI,SENCEFUL-MRI和儿童的FD-MRI的适用性和当前状态.
- 突出 NCE-MRI 在儿科肺功能评估中的优势.
主要方法:
- 通过MEDLINE,Embase,Cochrane图书馆,ClinicalTrials.gov和ICTRP进行系统的文献搜索.
- 纳入标准集中在肺部方面,特定的NCE-MRI技术 (MP-, PREFUL-, SENCEFUL-, FD-MRI) 和儿科人群.
- 对30份详细介绍儿童功能性NCE-MRI的报告进行分析.
主要成果:
- 功能性NCE-MRI已在各种肺部疾病的儿科观察研究中得到验证.
- 早期的研究报告了临床发现,而后来的研究强调临床主题.
- 不同类型的研究设计和协议限制了NCE-MRI技术的直接可比性.
结论:
- 由于其易于使用,NCE-MRI技术对广泛的临床采用非常有吸引力.
- 为了更广泛的实施,测试协议和结果计算方法的标准化是必要的.
- 需要进一步的研究来比较和标准化NCE-MRI技术,以获得一致的儿科肺部成像.
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