对焦虑和COVID-19之间的双向联系的分子见解:一种结合临床和生物信息学的方法
Wenjie Huang1, Biao Hu1, Chengyu Gu2
1Department of Pulmonary and Critical Care Medicine, Tongling Hospital Affiliated to Bengbu Medical University, Tongling, Anhui, China.
Frontiers in psychiatry
|August 6, 2025
概括
即使是无症状的COVID-19患者也表现出焦虑,与分子变化有关. 认知能力下降可能会通过炎症和脑部异常将COVID-19和焦虑联系起来.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19经常与增加的焦虑有关.
- 关联COVID-19和焦虑的分子机制尚未得到充分理解.
研究的目的:
- 为了调查无症状COVID-19患者的焦虑水平.
- 确定连接COVID-19和焦虑的分子途径和媒介.
- 探索认知功能在这种关联中的作用.
主要方法:
- 使用Zung自我评价焦虑量表 (SAS) 进行焦虑评估.
- 进行基于文献的数据挖掘来重建分子路径.
- 对八个COVID-19基因表达数据集进行了元分析.
主要成果:
- 大约25%的无症状COVID-19患者表现出轻度焦虑.
- COVID-19可能会导致通过多系统功能障碍和大脑异常导致认知能力下降.
- 观察到CALCA,TNF,PLAT和PPARG的表达增加,其中TNF,PLAT和PPARG与神经认知能力下降有关.
结论:
- 分子证据支持COVID-19和焦虑之间的双向联系.
- 失调的炎症细胞因子和分泌的蛋白质可能会调解这种关联.
- 认知功能受损是COVID-19和焦虑之间的潜在关键联系.
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