果多醇和肥胖成年人便秘的排便 - - 随机对照试验
Takahiro Sekikawa1, Yanmei Li2, Tsuyoshi Takara3
1BGG Japan Co., Ltd, Chuo-ku, Japan.
Journal of dietary supplements
|August 6, 2025
概括
果多醇显著增加了成年人便秘的每周排便频率. 这种未成熟的果提取物可以帮助缓解便秘症状,而不会影响肠道细菌,如Akkermansia muciniphila.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 人体生理学 人体生理学
背景情况:
- 便秘是一种常见的疾病,与心血管和脏疾病的风险增加有关.
- 确定有效的便秘干预措施对于公共卫生至关重要.
研究的目的:
- 为了评估未成熟果衍生的多醇对日本成年人经历便秘的排便频率的影响.
- 评估二次结果,包括便特征,肠道微生物群和代谢标志物.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及24名便秘参与者 (BMI ≥25 kg/m2).
- 参与者每天接受600毫克果多醇或安慰剂.
- 主要结局是每周排便的频率;次要结局包括便中的Akkermansia muciniphila数量和血液脂质概况.
主要成果:
- 与安慰剂组 (4.9 ± 1.4) (p=0.004) 相比,果聚烯组的每周排便频率显著更高 (7.0 ± 2.1).
- 两组之间没有观察到便中的Akkermansia muciniphila数量或身体组成的显著差异.
- 在果聚烯组中发现了较低血甘油三水平的趋势.
结论:
- 消费未成熟的果衍生的多醇可以有效地增加排便频率,并改善成年人的便秘.
- 在这个研究群体中,果多没有显著改变便中的Akkermansia muciniphila水平.
- 需要进一步的研究来探索果多在控制便秘方面的更广泛的健康影响和机制.
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