在听觉工作记忆过程中,背侧前额叶皮层的失活
Bethany Plakke1, Katryna Skye Kevelson2, Charles Leyens3
1Department of Psychological Sciences, Kansas State University, Manhattan, KS 66502, USA.
Journal of integrative neuroscience
|August 6, 2025
概括
脊侧前额叶皮层 (DLPFC) 失活并没有损害的听觉工作记忆 (WM). 这些发现表明DLPFC和腹侧前额皮层 (VLPFC) 在听觉WM中具有不同的作用.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 背侧前额皮质 (DLPFC) 参与工作记忆 (WM),特别是视觉空间WM.
- 关于其在听觉WM中的作用的证据是混合的,一些研究表明参与,而另一些研究则指向腹侧前额叶皮层 (VLPFC).
研究的目的:
- 研究DLPFC在听觉工作记忆中的作用.
- 为了比较DLPFC失活的影响与VLPFC失活对听觉WM表现的已知影响.
主要方法:
- 在使用皮层冷却的 rhesus macaques 中暂时禁用 DLPFC (46v,46d 和 9 区域).
- 在DLPFC的永久性伊波丁酸病变之后,对听觉WM任务执行的行为评估.
主要成果:
- DLPFC的皮层冷却失活并没有显著损害听觉WM的表现.
- DLPFC的伊波酸病变也没有显著改变听觉WM的表现.
- 暂时的失活导致一个受试者的目光厌恶增加,可能表明注意力或动机缺陷.
结论:
- DLPFC似乎没有在听觉工作记忆性能中发挥关键作用.
- 这些发现表明DLPFC和VLPFC在听觉WM中的功能分离,VLPFC可能具有更重要的作用.
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