税收1-PDZ相互作用的抑制剂通过改变EV组成来阻止HTLV-1病毒传播

Jedidja Puttemans1, Yasmine Brammerloo1, Karim Blibek1

  • 1Laboratory of Viral Interactomes, Unit of Molecular Biology of Diseases, GIGA Institute, University of Liege, Liège, Belgium.

概括

人类T细胞白血病病毒1型 (HTLV-1) 使用细胞外囊泡 (EV) 传播. 病毒Tax-1蛋白与人类的PDZ蛋白相互作用,改变了EV货物. 抑制这种相互作用会增加EV中的抗病毒因子,从而提供一种潜在的治疗策略.

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