尿道菌 (Streptococcus urinalis):一个由新型病原体引起的男性尿路炎的潜在病例
Jorge Ligero-López1, Antonio Beltrán-Rosel1,2,3, María Ducóns-Márquez4
1Clinical Microbiology Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
International journal of STD & AIDS
|August 6, 2025
概括
这项案例研究确定了Streptococcus urinalis作为男性持续性尿路炎的潜在原因,即使在对常见性传播感染进行初始治疗后也是如此. 需要进一步的研究来确认其在生殖尿路感染中的作用.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿路炎是一种常见的下尿路感染,经常与性传播感染 (STIs) 相关.
- 淋病菌和甲状腺炎是主要的病原体,但其他微生物,如Ureaplasma urealyticum也可能参与其中.
- 在非冠状腺球菌性尿路炎 (NGU) 病例中,很大一部分仍然是异常性,缺乏已确定的致病因子.
研究的目的:
- 报告男性尿路炎的病例,可能是由Streptococcus urinalis引起的.
- 突出在尿路炎中识别不常见病原体的诊断挑战.
主要方法:
- 一个37岁的男性在未经保护的性接触后出现尿路炎症状的临床表现.
- 最初的STI PCR对Ureaplasma urealyticum呈阳性,用阿齐思罗米治疗.
- 持续的症状导致尿道培养,MALDI-TOF MS和16S rRNA测序证实了Streptococcus urinalis.
主要成果:
- 最初发现并治疗了Ureaplasma urealyticum,但症状仍然存在.
- 经过多次尿道采样,始终能够分离出Streptococcus urinalis.
- 尿道菌 Streptococcus 隔离物对所有测试的抗生素都敏感.
结论:
- 这是第一个报告的病例,表明Streptococcus urinalis是男性尿路炎的潜在病原体.
- 持续的症状和反复的隔离支持S. urinalis在这种生殖尿路感染中的致病性.
- 这一案例有助于新出现的S. urinalis在生殖尿路感染中的证据.
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