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阻塞性睡眠呼吸暂停对认知的影响:对脑电图微态和阿尔法峰值频率的分析

Yan Wang^1,2, Ling Luo^1,3,4, Peilin Huang^1,3,4

¹Department of Neurology, Center for Cognitive Neurology, Fujian Medical University Union Hospital, Fuzhou, China.

CNS neuroscience & therapeutics

|August 6, 2025

概括

阻塞性睡眠呼吸暂停 (OSA) 与认知缺陷和焦虑有关. OSA患者表现出改变的脑电图 (EEG) 微态,这表明认知功能受损的网络机制.

科学领域:

神经科学是一个神经科学.
睡眠医学睡眠医学
认知心理学认知心理学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与认知障碍有关,包括注意力和记忆力缺陷.
患有OSA的患者经常经历情绪障碍,如抑郁和焦虑.
在OSA,电脑电图 (EEG) 微态和认知功能之间的关系仍然没有得到充分的研究.

研究的目的:

为了研究阻塞性睡眠呼吸暂停 (OSA) 患者的EEG微态特征.
探索EEG微态与OSA患者认知障碍之间的关联.
确定潜在的EEG网络机制,这些机制是OSA引起的认知缺陷的基础.

主要方法:

在70名患者身上进行了多睡眠扫描 (PSG),分为OSA (44) 和非OSA (26) 组.
收集的数据包括人口统计,生物样本,EEGα峰值频率和EEG微态.
用单词分类测试来评估认知功能.

主要成果:

患有OSA的患者表现出更高的焦虑症状率 (58.5%与29%) 和较低的分数在词的分类测试.
与非OSA对照组相比,OSA患者的微状态A持续时间增加,B向A微状态过渡率更高.
在OSA组中观察到F7-AV位置的Delta和Theta功率显著降低.

结论:

阻塞性睡眠呼吸暂停 (OSA) 通过EEG活动和微状态的改变影响认知功能和睡眠质量.
脑电图微态异常可能是OSA相关认知障碍的一个关键机制.
这些发现凸显了EEG微态作为OSA认知缺陷的生物标志物的潜力.

关键词:

电脑电脑电图微状态生物标志物生物标志物认知障碍是一种认知障碍.阻塞性睡眠呼吸暂停综合征 (OSA)

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