含有天然多化合物的吉兰配方,用于治疗口腔候群病
Narchonai Ganesan1, Lewis Oscar Felix1, Biswajit Mishra1
1Department of Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
Microbiology spectrum
|August 6, 2025
概括
含有咖啡酸乙烯 (CAPE) 和酸 (EA) 的新型凝膠膠 (GG) 配方對Candida albicans產生強烈的抗真菌活性,為口腔候群病 (OC) 提供有前途的治療方法. 这些生物相容的口服配方在模拟条件下有效地降低了真菌活力和生物膜形成.
科学领域:
- 生物材料科学 生物材料科学
- 菌类学 菌类学是指菌类学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 口腔候群病 (OC) 是一种由白菌候群 (Candida albicans) 引起的真菌感染,特别影响免疫力低下的个体,并表现出越来越强的抗药性.
- 目前的OC治疗面临挑战,包括生物可用性差,保留时间短,不良影响和患者坚持不良.
- 像咖啡酸乙烯 (CAPE) 和酸 (EA) 这样的多具有抗真菌和免疫调节性质,但需要改进的输送系统.
研究的目的:
- 开发和评估基于凝糖 (GG) 的配方,其中包括CAPE和EA,以提高对Candida albicans的疗效.
- 评估CAPE和EA装载的GG配方的抗真菌活性,生物膜抑制和菌根形成抑制.
- 在模拟的口服条件下调查开发的GG配方的药物释放概况和生物相容性.
主要方法:
- 格兰 (GG) 配方以不同的GG度 (0.6%和1.0%) 准备,加载CAPE (1,000μg/mL),EA (1,000μg/mL) 或两者.
- 对Candida albicans的抗真菌有效性进行了测试,测量了殖民地形成单位 (CFU),生物膜质量和菌根抑制.
- 使用人工模拟 (ACS) 分析了药物释放动力学,并使用人类红细胞和牙细胞评估了细胞毒性.
主要成果:
- 0.6%的GG配方显著降低了Candida albicans CFU (2-6 log10) 和生物膜质量 (高达CAPE + EA的70%).
- 两种0.6%和1.0%的GG配方都有效地抑制了真菌形的形成 (P < 0.0001).
- GG配方表现出与人体细胞的高生物相容性以及在ACS下持续释放CAPE和EA.
结论:
- 基于格兰的配方有效地提供CAPE和EA,对Candida albicans表现出显著的抗真菌活性.
- 这些配方在治疗口腔候群症方面表现有前途,因为它们在模拟的口腔条件下具有有效性,生物相容性和持续释放.
- 这项研究首次评估了CAPE/EA装载的GG配方在模拟下对Candida albicans进行评估,突出了它们对先进OC治疗的潜力.
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