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Updated: Sep 12, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

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抑郁症症状严重程度的早期变化与纳尔德-布普罗组合及其与减少甲基胺使用的关联在ADAPT-2试验中的甲基胺使用

Manish K Jha1, Udi E Ghitza2, Steve Shoptaw3

  • 1Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and the Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas.

The Journal of clinical psychiatry
|August 6, 2025
PubMed
概括

延长释放的纳尔特雷克松和布罗组合有效地减少了中度/严重的甲基胺使用障碍患者早期的抑郁症状. 这种早期的改善预测了随后的甲基胺使用量减少.

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Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence09:54

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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