案例报告:tigecycline诱导的公素升高
Benben Zhu1, Ting Yang2, Dongsheng Wang3
1Department of Pharmacy, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010050, People's Republic of China.
Naunyn-Schmiedeberg's archives of pharmacology
|August 6, 2025
概括
提格环素可以导致高甲素 (PCT) 水平,这是一个罕见的副作用. 在tigecycline治疗期间监测PCT至关重要,以避免误解感染状况,强调临床药剂师的重要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
- 生物化学 生物化学
背景情况:
- 前素 (PCT) 是一种细菌感染的生物标志物.
- 提格环素是一种广泛的抗生素,用于复杂的感染.
- 药物诱导的PCT水平的改变可能会使感染评估复杂化.
研究的目的:
- 报告一个由tigecycline引起的显著升的案例.
- 强调tigecycline可能干扰PCT解释的可能性.
- 强调需要警监测PCT在tigecycline治疗期间.
主要方法:
- 一个76岁的女性患者的病例报告.
- 监测 prokalcitonin (PCT) 和C反应蛋白 (CRP) 的水平.
- 观察PCT变化对tigecycline的使用和停药的反应.
主要成果:
- 在tigecycline治疗期间,PCT水平从0.628 ng/mL显著上升到5.944 ng/mL.
- 在停止服用提格环林后,PCT水平下降,在重新服用时增加.
- C-反应蛋白 (CRP) 水平保持稳定,这表明PCT升高不是由于感染恶化.
结论:
- 提格环素可能会诱导前素的升高,这是一个罕见的药物不良反应.
- 临床医生应考虑药物诱导的PCT变化,以避免误诊感染.
- 这一案例强调了临床药剂师在识别和管理药物不良反应方面的作用.
更多相关视频
05:28Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
3.7K
07:14Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
2.8K
相关概念视频
01:20Desensitization and Tachyphylaxis
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Several...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...