精制碳水化合物,不同主食的摄入量和与代谢功能障碍相关的脂肪性肝病的风险:一项前性基于社区的队列研究
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Updated: Sep 12, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Yurou Xu1, Xiajing Yao2, Youyi Wang1
1The Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
过度摄入精制碳水化合物和大米增加了与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险. 相反,食用小麦,粗谷物和可能会降低中国人口中MASLD的风险.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 有限的证据将精制碳水化合物和主食摄入量与代谢功能障碍相关的脂肪性肝病 (MASLD) 风险联系起来.
- 了解饮食因素对于预防MASLD至关重要,这是一个日益严重的全球健康问题.
研究的目的:
- 研究不同碳水化合物主食与中国成年人MASLD风险之间的关联.
- 为了探索饮食模式对MASLD发病率的影响,在一个大型的潜在队列中.
主要方法:
- 一项前性队列研究,涉及12134名来自上海郊区成人队列和生物银行的中国成年人.
- 通过经过验证的食物频率问卷评估的饮食摄入量;使用B模式超声波诊断的MASLD.
- 随访时间中位数为4.32年,确定了4447例MASLD病例.
主要成果:
- 较高的总精制碳水化合物和大米摄入量与MASLD发病率的增加相关 (HR分别为1.51和1.43).
- 小麦,粗谷物和洋与MASLD风险呈反向关联 (HR分别为0.78,0.86和0.78).
- 这些关联在女性中显著;用小麦或粗粮取代大米降低了MASLD风险.
结论:
- 过度摄入精制碳水化合物和大米与中国人口的MASLD风险有关.
- 增加小麦,粗谷物和的消费可能会对MASLD产生保护作用.
- 饮食模式在预防MASLD中发挥着重要作用,强调了主食选择的重要性.
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