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皮肤温度变化与睡眠呼吸暂停严重程度之间的关联:来自试点研究的发现
Gary Garcia Molina1,2, Trevor Winger3,4, Megha Rajam Rao3
1Sleep Number, Minneapolis, MN, USA. gmgarcia@wisc.edu.
在非快速眼动 (NREM) 睡眠期间减少皮肤温度变化 (STV) 与阻塞性睡眠呼吸暂停 (OSA) 严重程度有关. 这一发现表明,STV可能是一个有用的,非侵入性的工具,用于查OSA风险.
科学领域:
- 生理学 生理学 生理学
- 睡眠医学 睡眠医学
- 生物标志物 生物标志物
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 可以损害自主和血管调节,可能影响皮肤温度变化 (STV).
- 评估STV可能会提供有关OSA生理影响的见解.
研究的目的:
- 确定在远端和近端测量的STV是否与OSA严重程度相关 (呼吸暂停-呼吸暂停指数[AHI]和氧气不和[T90]).
- 评估STV作为OSA风险的非侵入性查工具的潜力.
主要方法:
- 在18名参与者身上,多睡眠学与同时记录远端和近端皮肤温度.
- 使用标准偏差,中位数绝对偏差和Poincaré图在不同睡眠阶段 (NREM,REM,觉醒) 的STV计算.
- 统计分析包括线性混合效应模型,BMI的调度分析和查潜力的ROC分析,并对p值进行FDR调整.
主要成果:
- 在NREM睡眠期间发现了AHI和远端STV之间的显著负相关性 (FDR调整后p < 0.001).
- 在NREM睡眠期间,T90还显示出与远端STV的显著负相关性 (FDR调整后p <0.01).
- 接收器运行特征 (ROC) 分析表明,对于中度至重度的OSA (AUC:0.93-0.97) 具有很高的辨别能力.
结论:
- 在NREM睡眠期间远端STV减少是OSA严重程度的独立指标.
- 作为一种有效查阻塞性睡眠呼吸暂停风险的非侵入性生物标志物,STV显示出前景.
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