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Updated: Sep 8, 2025

4D Imaging of Protein Aggregation in Live Cells
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4D Imaging of Protein Aggregation in Live Cells

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解码蛋白稳定:对聚合,溶性和展开机制的影响

Martin Havlásek1,2, Sérgio M Marques1,2, Veronika Szotkowská1

  • 1Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno 611 37, Czech Republic.

Journal of chemical information and modeling
|August 6, 2025
PubMed
概括

在醇脱基酶中稳定突变可能会意外地降低溶解度. 这项研究揭示了密码聚合易发生的区域和增加的表面水性作为导致工程蛋白质溶解率降低的关键因素.

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