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Updated: Sep 12, 2025

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

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时间解析的光催化接近性标记揭示了ER蛋白质组动力学,这是UPR-to-apoptosis过渡的基础

Nan Zhou1, Yan Zhang1,2, Peng R Chen1,2

  • 1Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 6, 2025
PubMed
概括

我们开发了CAT-ER,这是一种非遗传方法,用于in situ内质网膜 (ER) 蛋白质组学. 该工具揭示了在压力诱导的亡过程中ER蛋白质组的动态变化,为细胞死亡途径提供了新的见解.

关键词:
灭症 (apoptosis) 是一种死亡的过程.细胞内膜网膜的内oplasmic网膜.接近性标签的标签.亚细胞蛋白质组学不折叠的蛋白质反应反应

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Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells09:34

Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells

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