在子宫内膜癌队列中的HER2表达
Kari E Hacker1, Kathryn A Fleming1, Mamta Gupta2
1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laura and Isacc Perlmutter Cancer Center, NYU Langone Health, New York, NY, United States of America.
大约60%的子宫内膜癌 (EC) 表达HER2. 超过三分之一的这些瘤 (30.5%) 显示HER2 2+或3+表达,可能使他们有资格获得HER2定向抗体-药物合物 (ADC).
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症生物标志物 癌症生物标志物
- 翻译医学是一种翻译医学.
背景情况:
- 特拉斯图祖马布德鲁克斯泰坎是一种HER2抗体-药物联合体 (ADC),在表达HER2的妇科癌症中显示出有效性.
- 子宫内膜癌 (EC) 是一种常见的妇科恶性瘤,具有不同的HER2表达特征.
研究的目的:
- 确定HER2表达在子宫内膜癌 (EC) 的流行率.
- 确定符合HER2向抗体-药物合物 (ADC) 的EC患者比例.
主要方法:
- 对249名经过手术治疗的EC患者进行了回顾性分析.
- 在220个瘤中进行了HER2免疫组织化学 (IHC),在模两可的病例中进行了反射FISH (2+).
- 用于分析HER2表达和临床病理学变量之间的关联的奇平方测试.
主要成果:
- 在59.5%的EC瘤中观察到HER2表达 (IHC 1+,2+,或3+).
- 很大一部分 (30.5%) 呈现2+或3+的HER2表达.
- 在晚期疾病和非子宫内膜组织学中,表达HER2的瘤更为频繁.
结论:
- 近60%的新诊断的EC患者通过IHC显示HER2的表达.
- 大约三分之一的EC患者可能是HER2导向ADC的候选人.
- 建议对所有子宫内膜瘤进行HER2 IHC测试,因为它在各个亚型中表达.
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